GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs910316 | 1 | rs4899544 | chr14:75546556 | MLH3 | chr14:75480467-75518235:- | 0.3 | 9.04 | 3.85E-18 | Height |
| THCA | cis | rs910316 | 1 | rs4899544 | chr14:75546556 | RPS6KL1 | chr14:75372347-75389958:- | 0.32 | 6.92 | 1.5E-11 | Height |
| THCA | cis | rs910316 | 1 | rs4899546 | chr14:75594946 | EIF2B2 | chr14:75469612-75476292:+ | 0.19 | 5.12 | 4.5E-7 | Height |
| THCA | cis | rs910316 | 1 | rs4899546 | chr14:75594946 | MLH3 | chr14:75480467-75518235:- | 0.3 | 8.98 | 6.21E-18 | Height |
| THCA | cis | rs910316 | 1 | rs4899546 | chr14:75594946 | RPS6KL1 | chr14:75372347-75389958:- | 0.32 | 6.87 | 1.95E-11 | Height |
| THCA | cis | rs935334 | 1 | rs4899586 | chr14:76660856 | ESRRB | chr14:76837690-76968178:+ | 0.32 | 5.22 | 2.74E-7 | Blood pressure |
| THCA | cis | rs4905558 | 1 | rs4900349 | chr14:97278022 | VRK1 | chr14:97263684-97347950:+ | 0.17 | 3.99 | 7.51E-5 | Neutrophil count |
| THCA | cis | rs1982963 | 1 | rs4901186 | chr14:52509484 | C14orf166 | chr14:52456228-52471419:+ | -0.13 | -3.83 | 0.000148 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs1982963 | 1 | rs4901186 | chr14:52509484 | NID2 | chr14:52471521-52535946:- | -0.18 | -3.66 | 0.000279 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs17102423 | 1 | rs4902364 | chr14:65602006 | FNTB | chr14:65381140-65529369:+ | -0.23 | -4.56 | 6.43E-6 | Obesity-related traits |
| THCA | cis | rs17102423 | 1 | rs4902365 | chr14:65602064 | FNTB | chr14:65381140-65529369:+ | -0.22 | -4.54 | 7.18E-6 | Obesity-related traits |
| THCA | cis | rs7147624 | 1 | rs4902408 | chr14:66111901 | LOC645431 | chr14:65877313-65879335:- | 0.26 | 3.77 | 0.000185 | Chronic obstructive pulmonary disease-related biomarkers |
| THCA | cis | rs2239557 | 1 | rs4903201 | chr14:74659690 | C14orf45 | chr14:74486059-74549566:+ | -0.16 | -4.58 | 6.0E-6 | Common traits (Other) |
| THCA | cis | rs2239557 | 1 | rs4903201 | chr14:74659690 | COQ6 | chr14:74416643-74429811:+ | -0.13 | -3.62 | 0.000329 | Common traits (Other) |
| THCA | cis | rs2239557 | 1 | rs4903201 | chr14:74659690 | LIN52 | chr14:74551656-74667117:+ | -0.51 | -13.7 | 2.72E-36 | Common traits (Other) |